Adventitious Viruses and Smallpox Vaccine
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منابع مشابه
Adventitious Viruses and Smallpox Vaccine
To the Editor: Recently, Murphy and Osburn (1) strongly argued for testing old smallpox vaccine stocks made in animal skin for adventitious infectious agents such as viruses, mycoplasmas, and eventually, prions. Their argument appears clearly justified after unexpected cases of myopericarditis occurred during recent campaigns of smallpox vaccinations in the United States (2). To the long list o...
متن کاملAdventitious Agents and Smallpox Vaccine in Strategic National Stockpile
In keeping with current standards, we urge that old smallpox vaccines that were made in animal skin and are still a key part of our strategic national stockpile be tested for adventitious infectious agents. The advisory especially applies to viruses that have the potential for zoonotic transmission to human vaccine recipients.
متن کاملShared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses.
The concern about bioterrorism with smallpox has raised the possibility of widespread vaccination, but the greater prevalence of immunocompromised individuals today requires a safer vaccine, and the mechanisms of protection are not well understood. Here we show that, at sufficient doses, the protection provided by both modified vaccinia Ankara and NYVAC replication-deficient vaccinia viruses, s...
متن کاملCurrent status of smallpox vaccine.
To the Editor: The possible use of smallpox virus as a weapon by terrorists has stimulated growing international concern and led to a recent review by the World Health Organization of the global availability of smallpox vaccine. This review found approximately 60 million doses worldwide, with little current vaccine manufacture, although limited vaccine seed remains available (1). Ongoing discus...
متن کاملDose-related effects of smallpox vaccine.
BACKGROUND We conducted a double-blind, randomized trial of three dilutions of vaccinia virus vaccine in previously unimmunized adults in order to assess the clinical success rates, humoral responses, and virus-specific activity of cytotoxic T cells and interferon-gamma-producing T cells. METHODS Sixty healthy adults were inoculated intradermally by bifurcated needle with undiluted vaccine (d...
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ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 2005
ISSN: 1080-6040,1080-6059
DOI: 10.3201/eid1111.051031